Wang S, Tang J, Zhao H, Wana J, Chen K (2014) Synthesis of magnetite silica core-shell nanoparticles via direct silicon oxidation. Wiley Interdiscip Rev Nanomed Nanobiotechnol 9(6):1468 Vuong QL, Gillis P, Roch A, Gossuin Y (2017) Magnetic resonance relaxation induced by superparamagnetic particles used as contrast agents in magnetic resonance imaging: a theoretical review. Kolhatkar AG, Jamison AC, Litvinov D, Willson RC, Lee TR (2013) Tuning the magnetic properties of nanoparticles. RSC Adv 7(15):8786–8797Ĭolombo M, Carregal-Romero S, Casula MF, Gutierez L, Morales MP, Bohm IBJT, Heverhagen, Prosperi D, Parak WJ (2012) Biological applications of magnetic nanoparticles. Kostiv U, Patsula V, Šlouf M, Pongrac IM, Škokić S, Radmilović MD, Pavičić I, Vrček IV, Gajović S, Horák D (2017) Physico-chemical characteristics, biocompatibility, and MRI applicability of novel monodisperse PEG-modified magnetic Fe 3O 4 &SiO 2 core–shell nanoparticles. Shen L, Li B, Qiao Y (2018) Fe 3O 4 nanoparticles in targeted drug/gene delivery systems. Knezevic NZ, Slowing II, Lin VSY (2012) Tuning the release of anticancer drugs from magnetic iron oxide/mesoporous silica core/shell nanoparticles. Ruiz-Hernandez E, Lopez-Noriega A, Arcos D, Izquierdo-Barba I, Terasaki O, Vallet-Regi M (2007) Aerosol-assisted synthesis of magnetic mesoporous silica spheres for drug targeting. Yuan L, Tang Q, Yang D, Zhang JZ, Zhang F, Hu J (2011) Preparation of pH-responsive mesoporous silica nanoparticles and their application in controlled drug delivery. Kim J, Kim HS, Lee N, Kim T, Kim H, Yu T, Hyeon T (2008) Multifunctional uniform nanoparticles composed of a magnetite nanocrystal core and a mesoporous silica shell for magnetic resonance and fluorescence imaging and for drug delivery. Lu F, Wu SH, Hung Y, Mou CY (2009) Size effect on cell uptake in well‐suspended, uniform mesoporous silica nanoparticles. J Microporous Mesoporous Mater 120:246–251 Sen T, Bruce IJ (2009) Mesoporous silica-magnetite nanocomposites: fabrication, characterisation and applications in biosciences. Zhao W, Gu J, Zhang L, Chen H, Shi J (2005) Fabrication of uniform magnetic nanocomposite spheres with a magnetic core/mesoporous silica shell structure. J Microporous Mesoporous Mater 145:217–223 Xia M, Chen C, Long M, Chen C, Cai W, Zhou B (2011) Magnetically separable mesoporous silica nanocomposite and its application in Fenton catalysis. Jin C, Wang Y, Wei H, Tang H, Liu X, Lu T, Wang J (2014) Magnetic iron oxide nanoparticles coated by hierarchically structured silica: a highly stable nanocomposite system and ideal catalyst support. Zhang M, Fang K, Lin M, Hou B, Zhong L, Zhu Y, Wei W, Sun Y (2013) Controlled fabrication of iron oxide/mesoporous silica core–shell nanostructures. J Ind Eng Chem Res 48:3441–3445ĭeng Y, Qi D, Deng C, Zhang X, Zhao D (2008) Superparamagnetic high-magnetization microspheres with an Fe 3O 2 core and perpendicularly aligned mesoporous SiO 2 shell for removal of microcystins. J Chem Soc 130:2154–2155Ĭhen Z, Zhuo M, Xue F, Chen J, Xu Q (2009) Preparation of magnetically separable mesoporous silica microspheres with open pore systems in supercritical carbon dioxide. Taylor KML, Kim JS, Rieter WJ, An H, Lin W, Lin W, Am J (2008) Mesoporous silica nano spheres as highly efficient MRI contrast agents. Ge J, Zhang Q, Zhang T, Yin Y (2008) Core–satellite nanocomposite catalysts protected by a porous silica shell: controllable reactivity, high stability, and magnetic recyclability. In comparison to other multi-step synthesis techniques, the results obtained from this research confirmed the formation of magnetite-silica core-shell structures with the desired magnetic behavior in a quick and single-step process. Due to the high ratio of core size to shell thickness, the magnetic saturation for the synthetized core-shell nanoparticles in this research was significant. A study of the magnetic characteristics showed super-paramagnetic behavior with 60 emu/g saturation magnetization (M s). The mean core and shell size were estimated to be about 20 and 2.5 nm, respectively. TEM images showed the presence of nanocomposite particles with core-shell structure of 25 nm diameter. XRD analysis confirmed the existence of both magnetite and silica phases in the final structure. In addition, vibrating sample magnetometer (VSM) was used to evaluate the magnetic characteristics. The structural and morphological characteristics of core-shell nanoparticles were examined by XRD, TEM, SEM, and BET analyses. Synthesis was performed at 80 ☌ with stirring at 12,000 rpm in an alkaline medium. In the first step, the magnetite nanoparticles were prepared by co-precipitation method and silica shell was immediately formed by the sol-gel process. In this study, a specific technique was used to quickly, easily, and single step, synthesize core-shell magnetite-silica nanoparticles by controlling the reaction conditions using the proper surfactant.

Core shell nanoparticles